Giants picks, you need to see the NFL predictions and betting advice from SportsLine's Advanced Computer Model.
49ers odds, while the over/under for total points scored is 44. San Francisco is a 10.5-point favorite in the latest Giants vs. Kickoff from Levi's Stadium is set for 8:15 p.m. The 49ers will be without wide receiver Brandin Aiyuk (shoulder). The Giants will be without star running back Saquon Barkley, who suffered an ankle injury last week. New York (1-1) visits San Francisco for the first time since 2018 after staging a 21-point comeback, the team's largest of the Super Bowl era, in a 31-28 triumph at Arizona in Week 2. The 49ers (2-0) began the campaign with road victories against Pittsburgh and the NFC West-rival Los Angeles Rams to extend their regular-season winning streak to 12 games. Week 3 of the 2023 NFL schedule gets underway when the San Francisco 49ers play their home opener against the New York Giants on Thursday Night Football.